Parkinson's is a disease that creates new challenges as it progresses. Motor symptoms may worsen over time, and the changes patients face may leave them feeling out of control. Doctors may recommend different management strategies at different stages, adjusting medications and dosages to try to manage symptoms effectively while minimizing side effects.
As Parkinson's progresses, it may be harder and harder to control motor symptoms. Why? One theory is that the levodopa window narrows over time, so that you may notice more "off" time* and less "on" time.†
Dyskinesia: Involuntary movements, one potential side effect of medicines. This may occur when medicine levels are too high.
"On" time: When your medication is working well.
"Off" time: When your medication isn't working and you feel stiff, move slowly, or have trouble getting around.
*Periods of slowness, stiffness, and impaired mobility when medication is not working optimally.
†Periods when medicine is providing benefit for Parkinson's symptoms such as impaired mobility, slowness, and stiffness.
In Parkinson's disease, due to variety of factors including changes in the nervous system of the gut and brain, the stomach may not contract and empty with regularity. It may be faster or slower than usual. This may result in your medicine not being made available where it is needed.